牛效迪，男，1978年12月出生，博士，教授，博士生导师。主要从事抗食源性病原菌药物设计、食品安全检测及分子药理学等研究，成功建立中药抗菌成分作用靶标及分子作用机制的分析和验证平台。主持和参与了多项国家级项目，包括国家自然科学基金面上项目、国家自然基金重点项目及科技部973项目等。目前，在国际期刊上发表SCI论文20余篇，其中影响因子5以上论文5篇。

学术任职：

吉林省食品学会理事

学习工作经历：

1998～2002年在东北师范大学化学学院学习，获学士学位。

2002～2005年在东北师范大学化学学院学习，获硕士学位。

2005～2008年在中科经理春应用化学研究所学习，获博士学位。

2008～至今在永利总站线路检测军需科技学院工作，讲师、副教授，硕士生导师。

2009～2011年进入军事医学科学院基础兽医学专业博士后流动站。

主持项目：

[1] 国家自然科学基金面上项目，《木犀草素抗李斯特菌感染的分子机制》，31572566，2016/01-2019/12，77.2万元，在研，主持

[2]中国博士后一等面上资助，8万元，在研，主持

[3]中国博士后特别资助，15万元，在研，主持

[4] 国家自然基金重点项目子课题项目-《溶血素-药物小分子复合物分子动力学模拟》(3A2110026603)

[5]  科技部973项目子课题项目-《抗金葡萄溶血素天然化合物筛选》(3F012J606201)

[6]  永利总站线路检测博士科研启动基金-《食源性多酚类抗氧化剂活性机制研究》

发表论文：

[1] Wang, Jianfeng ，Qiu, Jiazhang ，Tan, Wei，Zhang, Yu，Wang, Hongshu，Zhou, Xuan，Liu, Shui，Feng, Haihua，Li, Wenhua，Niu, Xiaodi(*)，Deng, Xuming(*)，Fisetin Inhibits Listeria monocytogenes Virulence by InterferingWith the Oligomerization of Listeriolysin O.，The Journal of Infectious Diseases，2015，211：1376-1387。(影响因子：6.288)

[2] Wang, Jianfeng ，Zhou, Xuan ，Liu, Shui ，Li, Gen，Zhang, Bing，Deng, Xuming(*)，Niu, Xiaodi(*)，Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin via protein-ligand modeling，Scientific Reports，2015，5：8864。(影响因子：5.228)

[3] Li, Hongen ，Zhao, Xiaoran ，Wang, Jianfeng，Dong, Yu，Meng, Song，Li, Rui，Niu, Xiaodi(*)，Deng, Xuming(*)，beta-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection，Scientific Reports，2015，5：17668。(影响因子：5.228)

[4] Xiaoran Zhao ，Hongen Li，Jianfeng Wang，Yan Guo，Bowen Liu，Xuming Deng(*)，Niu, Xiaodi(*)，Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers，MOLECULAR PHARMACOLOGY，2016，89：376–387。(影响因子：3.931)

[5] Wang, Jianfeng ，Zhou, Xuan ，Liu, Shui，Li, Gen，Shi, Lei，Dong, Jing，Li, Wenhua，Deng, Xuming(*)，Niu, Xiaodi(*)，Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of α-hemolysin，Journal of Applied Microbiology，2015，118：753-763。(影响因子：2.156)

[6] Wang, Lin ，Bi, Chongwei ，Cai, Hongjun，Liu, Bingrun，Zhong, Xiaobo，Deng, Xuming，Wang, Tiedong，Xiang, Hua，Niu, Xiaodi(*)，Wang, Dacheng(*)，The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition，Frontiers in Microbiology，2015，6：1031。(影响因子：3.989)

[7] Liu, Bingrun ，Chen, Fuguang ，Bi, Chongwei ，Wang, Lin，Zhong, Xiaobo，Cai, Hongjun，Deng, Xuming，Niu, Xiaodi(*)，Wang, Dacheng(*)，Quercitrin, an Inhibitor of Sortase A, Interferes with the Adhesion of Staphylococcal aureus，Molecules，2015，20：6533-6543 (影响因子：2.416)

[8] Jing Dong, Jiazhang Qiu, Yu  Zhang, Chongjian Lu, Xiaohan Dai, Jianfeng Wang, Hongen Li,Xin Wang, Wei Tan,  Mingjing Luo, Xiaodi Niu (通讯作者), Xuming Deng. Oroxylin A Inhibits Hemolysis via  Hindering the Self-Assembly of a-Hemolysin Heptameric Transmembrane Pore. PLoS  Computational Biology, 2013, 21: e1002869 (影响因子：5.216)

[9] Xiaodi Niu, Jiazhang Qiu,  Xin Wang, Xiaohan Gao, Jing Dong, Jianfeng Wang, Hongen Li, Yu Zhang, Xiaohan  Dai, Chongjian Lu, Xuming Deng. Molecular insight into the inhibition mechanism  of cyrtominetin to a-hemolysin by molecular dynamics simulation. European  Journal of Medicinal Chemistry, 2013, 62: 320-328 (影响因子：3.346)

[10] Yu Zhang, Jian-feng Wang,  Jing Dong, Jing-yuan Wei, Ya-nan Wang, Xiao-han Dai, Xin Wang, Ming-jing Luo,  Wei Tan, Xu-ming Deng, Xiao-di Niu(通讯作者). Inhibition of α-toxin production by  subinhibitory concentrations of naringenin controls Staphylococcus aureus  pneumonia. Fitoterapia, 2013, 86,92-99. (影响因子：1.848)

[11] XinWang, Jing Dong, Xiaohan  Dai, Yu Zhang, JianfengWang, Hongen Li, Chongjian Lu,Wei Tan, Xiaohan Gao,  Xuming Deng, Shijin Bu, Xiaodi Niu(通讯作者). Silibinin In Vitro Protects A549 Cells  from Staphylococcus aureus-Mediated Injury and In Vivo Alleviates the Lung  Injury of Staphylococcal Pneumonia. Planta Med, 2013, 79: 110–115 (影响因子：2.153)  

[12] Xiaodi Niu, Jing Dong,  Dacheng Wang, Jianfeng Wang, Hongen Li, Mingjing Luo, Shentao Li, Haihua Feng,  and Xuming Deng. Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via  Inhibition of the Cytolytic Activity of α-Hemolysin. The Journal of Infectious Diseases, 2012, 206:292–301 (影响因子：6.288)

[13] Xiaodi Niu, Jianfeng Wang,  Yan Xing, Bingfeng Leng, Jing Dong, Hongen Li, Mingjing Luo, Yu Zhang, Xiaohan  Dai, Yonghuang Luo, Xuming Deng. Capsaicin Protects Mice from  Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonia. PLoS ONE, 2012, 7:e33032 (影响因子：4.092)

[14] Hongsu Wang, Xiaohan Gao,  Yanan Wang, Jinglong Tang, Cancan Sun, Xuliang Deng, Xiaodi Niu(通讯作者).  Bio-templated synthesis of mesoporous bioactive glass with a hierarchical pore  structure. Materials Letters, 2012, 76:237-239 (影响因子：2.307)

[15] Xiaodi Niu, Xiaohan Gao,  Hongsu Wang, Xin Wang, Song Wang. Insight into the dynamic interaction between  different flavonoids and bovine serum albumin using molecular dynamics  simulations and free energy calculations. J. Mol. Model. 2013, 19:1039-1047 (影响因子：1.797)

[16] Xiaodi Niu, Xin Wang,  Hongsu Wang, Xiaohan Gao, Yanan Wang, Song Wang. Insights into the specific  binding site of adenosine to the Stx2, the protein toxin from Escherichia coli  O157:H7 using molecular dynamics simulations and free energy calculations.  Molecular Simulation, 2013, DOI:10.1080/08927022.2012.713483 (影响因子：1.328)  

[17] Hongsu Wang, XiaohanGao,  YananWang, JianfengWang, Xiaodi Niu(通讯作者), XuliangDeng. Effect of amine  functionalization of SBA-15 on controlled baicalin drug release. Ceramics  International, 2012, 38: 6931-6935 (影响因子：1.751)

[18] Xiaodi Niu, Hongsu Wang,  Jingbo Liu. Efficient green-phosphorescent light-emitting diodes based on  polymeric binary-host systems. Journal of Luminescence. 2011, 131: 2589-2592  (影响因子：2.102)

[19] Han Weiwei, Wang Ye, Luo  Quan, Xiaodi Niu (通讯作者). INSIGHTS INTO A 3D HOMOLOGY MODEL OF ARYLESTERASE: THE  KEY RESIDUES UPON PROTEIN-LIGAND DOCKING AND MM-PBSA CALCULATIONS. JOURNAL OF  THEORETICAL & COMPUTATIONAL CHEMISTRY, 2011, 10: 165-177 (影响因子：0.561)  

[20] Xiaodi Niu, Baohua Zhang,  Zhiyuan Xie, Yanxiang Cheng, and Lixiang Wang. Balanced charge transport and  enhanced white electroluminescence from a single white emissive polymer via  thermal annealing. APPLIED PHYSICS LETTERS, 2010, 96: 073303 (影响因子：3.844)  

[21] Xiaodi Niu, Jingbo Liu,  Zhiyuan Xie. Efficient white polymer light-emitting diodes based on the control  of a emissive polymer morphology through solvent processing. Organic  Electronics, 2010, 11, 1273-1276 (影响因子：4.047)

[22] Xiaodi Niu, Chuanjiang  Qin, Baohua Zhang, Junwei Yang, Zhiyuan Xie. Efficient multilayer white polymer  light-emitting diodes with aluminum cathodes. APPLIED PHYSICS LETTERS, 2007, 90:  203513 (影响因子：3.844)

[23] Xiaodi Niu, Liang Ma, Bing  Yao, Junqiao Ding, Zhiyuan Xie. white polymeric light-emitting diodes with high  color rendering index. APPLIED PHYSICS LETTERS, 2006, 89: 213508 (影响因子：3.844)  

[24] 牛效迪，刘静波，王嵩，王虹苏.  以膦酸酯聚芴作为阴极界面修饰层的高效聚合物红光电致发光器件. 高等学校化学学报，2010,9：1-4.

[25] Zhuo Lv, Hong S. Wang,  Xiao D. Niu*. Molecular dynamics simulations reveal insight into key structural  elements of aaptamines as sortase inhibitors with free energy calculations.  Chemical Physics Letters, 2013, 585, 171-177. (影响因子：2.147)

联系方式：

联系电话：0431－87836365

电子信箱：niuxd@jlu.edu.cn